PBPK Modeling

***A new offering of this course is tentatively planned for Spring 2016.  Please check back for more updates.***

Course Description

This one-week course will cover the fit-for-purpose paradigm for in vitro toxicity testing. We will cover principles of physiologically based pharmacokinetic modeling and computational biology, with an emphasis on applications for toxicological safety assessment. The course features comprehensive lectures and extensive hands-on computer modeling exercises.

Who should attend?

This course is designed to serve a variety of scientific communities.

  • Anyone interested in using developing cell-based toxicity assays using pathway biology as a guide.
  • Researchers and regulators wanting to develop or interpret high-throughput assays such as those used in Tox21 or ToxCast.
  • Industrial, pharmaceutical and regulatory scientists desiring to interpret the results of in vitro or in vivo toxicity assays in terms of their implications for human health.
  • Individuals who would like to link dosimetry models to biologically-based cellular response models.
  • Individuals interested in promoting the use of alternatives to live animal testing for regulatory requirements such as REACH.

Why should you attend?

Upon completion of this course you will be able to:

  • Draw from existing high-throughput datasets to help interpret your experiments.
  • Understand how the structure of a signal transduction pathway shapes its behavior.
  • Use Berkeley Madonna® to evaluate PBPK models and simulate intracellular signaling networks.
  • Take first steps to develop cell signaling models to describe pathway perturbations.
  • Understand the fundamental concepts underlying physiologically based pharmacokinetic (PBPK) modeling.
  • Link PBPK models with other biologically based computational tools, such as pharmaco-dynamic modeling and cell signaling pathway modeling.


Previous Courses

Select a link to read more about that year's course.

Physiologically Based Pharmacokinetic (PBPK) Modeling Workshops