Education & Training
A Course on Interpretation of Biomonitoring Data Using Physiologically Based Pharmacokinetic (PBPK) Modeling
September 25 – 29, 2006
The Center for Human Health Assessment
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Day 1
Pharmacokinetic Modeling and Biomonitoring
Demonstration of Berkeley Madonna
Simulation Languages for PBPK Modeling
Exercise 1: A One-Compartment Model for Methyl Mercury
Exercise 2: A Half-Life by Any Other Name...
Day 2
Constructing PK Models
PBPK Model Parameterization and Evaluation
Exercise 1: Inhalation Model for Styrene
Exercise 2: Poorly Cleared Lipophilic Compounds
Day 3
Introduction to Biomonitoring
Application of Modeling to Interpret Biomonitoring Data
Exercise 1: A PBPK Model for Methyl Mercury
Exercise 2: Using a PBPK Model to Reconstruct a Trichloroethylene (TCE) Exposure
Day 4
Exposure Modeling
Reverse Dosimetry in Risk Estimation in a Population
Exercise 1: Reverse Dosimetry
Exercise 2: Dietary Exposure to Bisphenol A
Day 5
Analysis of Biomonitoring Data to Estimate Early LIfe Exposures
Tailoring PK Models for Biomonitoring Studies