Education & Training
Physiologically Based
Pharmacokinetic (PBPK)
Modeling and Risk Assessment Workshop
February 11 – February 15, 2008
The Center for Human Health Assessment
Learn how to use state-of-the-art modeling techniques
for tissue dosimetry:
- Applying integrative and quantitative tools for human health effects research
- Reducing uncertainties in estimating the effects of chemicals in human populations
Download course files
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Day 1
Pharmacokinetics in Toxicology Research
A Brief History of Physiologically Based Modeling
Demonstration of Berkeley Madonna
Exercise 1: Building a 2-Compartment Model
Exercise 2: 1-Compartment Fat Model
Exercise 3: 1-Compartment Isolated Perfused Liver Model
Exercise 4: Protein Binding in Tissue and Blood
Day 2
Construction of a Physiologically Based Pharmacokinetic Model
Clearance in PBPK Models
Exercise 1: 3-Compartment IV Model for 2,2',4,4',5,5'-Hexa-chlorobiphenyl (6CB)
Exercise 2: A Half-life by Any Other Name...
Exercise 3: Inhalation Model for Styrene: Cross-Route and Cross-Species Extrapolation
Day 3
PBPK Modeling: Parameter Estimation
Application of PBPK Modeling in Non-cancer Risk Assessment
Exercise 1: Dose-dependent Disposition Model for Dioxin in the Growing Rat
Exercise 2: Poorly Cleared Lipophilic Compounds - Risk Assessment Considerations
Day 4
Uncertainty Analysis in PBPK Modeling
Application of PBPK Modeling in Cancer Risk Assessment
Exercise 1: PBPK Modeling of Vinyl Chloride
Exercise 2: Using PBPK Models to Perform Dosimetry Needed in Non-Cancer Risk Assessment
Day 5
PBPK Modeling with Metabolites: Examples & Issues
Pharmacokinetic Models During Perinatal Development
Simulation Language for PBPK Modeling
Exercise: PBPK Modeling with Metabolites