Center for Human Health Assessment

Overview

By combining computational modeling of tissue dosimetry and cellular response with targeted in vitro studies, the Center for Human Health Assessment is forging a new era for human health risk assessments based on perturbation of human biology rather than on uncertain extrapolations from high-dose responses in rodents. These approaches also hold promise for accelerating the development of new pharmaceuticals and providing superior alternatives to live animal testing.

Health Assessment Experience

  • The Hamner has pioneered the application of a systems biology approach to provide integrative and quantitative tools for human health effects research.
  • Scientists affiliated with the Center for Human Health Assessment have a long history of seminal research on the effects of chemicals on human health.
  • The Hamner has well-established collaborative relationships with area research facilities and government agencies.
  • Safety and risk assessments developed for specific compounds by The Hamner staff have served as templates for similar assessments of other compounds.

Leadership

Miyoung Yoon, Ph.D., Director

Miyoung Yoon, Ph.D., serves as Director of The Center for Human Health Assessment at The Hamner Institutes for Health Sciences, and is a Hamner Assistant Investigator.  Dr. Yoon’s research has coupled biologically based kinetic modeling with targeted in vitro studies to improve human health risk assessment.  In her current research, she works to improve in vitro to in vivo extrapolation modeling in order to estimate safe human exposures for various environmental compounds of human health concern. Dr. Yoon received her Ph.D. in Pharmacy from Seoul National University in Seoul, South Korea. Dr. Yoon’s work has been recognized by the Risk Assessment and Biological Modeling Specialty Sections of the Society of Toxicology as best abstracts and papers and by Toxicological Sciences as honorable mention for board of publications best paper. Dr. Yoon is author/coauthor of more than 35 publications including peer-reviewed articles and book chapters. She has served as guest editor of the special issue of Toxicology on the topic of Quantitative In Vitro to In Vivo Extrapolation: an essential element for in vitro-based risk assessment. Dr. Yoon also has been actively providing training courses for PBPK modeling and its applications. She has been a member of the SOT since 2004 and has served as Councilor of the Biological Modeling Specialty Section. She is also a member of the American Society for Cellular and Computational Toxicology (ASCCT).

Affiliated Scientists

Melvin E. Andersen, Ph.D., DABT, CIH

Jerry Campbell, Jr., Ph.D.

Harvey J. Clewell III, Ph.D., DABT

Miyoung Yoon, Ph.D.

Cory Strope, Ph.D.