Darol E. Dodd, Ph.D., DABT
The Hamner has developed extensive resources to provide sponsored research services as well as support and services to the research programs aligned with its Institutes and Centers. Extensive capabilities in inhalation exposure and aerosol sciences, pharmacokinetics, and general toxicology are available to conduct preclinical safety studies of chemical compounds and drug candidates. Quality assurance (QA) and quality control (QC) procedures are an integral component of The Hamner’s Research Services. If necessary, preclinical safety studies can be conducted under Good Laboratory Practice (GLP) standards as defined by U.S. EPA regulations.
The Hamner’s Research Services are broadly categorized into areas of Preclinical Safety, Inhalation Exposure and Aerosol Sciences, and Additional Capabilities. Preclinical Safety includes general toxicology, pharmacokinetics, toxicokinetics, and carcinogenicity studies. Inhalation projects are conducted in a dedicated and specialized facility. Gases, vapors, dusts, aerosols, and nanoparticles are generated and characterized in whole-body or nose-only animal exposure chambers. Additional Capabilities at The Hamner include necropsy, histology, histopathology, and specialized instrument (e.g., flow cytometry, electron microscopy, confocal microscopy, laser-scanning capture microscopy) expertise.
Representative Research Services and Capabilities
- Fibrogenicity study of inhaled amphibole asbestos in rats
- Rodent carcinogenicity study of methyl tert-butyl ether in drinking water
- Mode-of-action (genomics) study of naphthalene vapor in rats
- In vitro/in vivo mode-of-action study of chromium VI (high-content imaging in cells and genomics in rat tissues)
Darol E. Dodd, Ph.D., DABT, is a Hamner Senior Research Toxicologist, and Manager of Research Support Services. Dr. Dodd conducts research on the adverse effects and mode of action of xenobiotics on laboratory animals or cell systems. Dr. Dodd has 30 years of experience directing and managing mammalian toxicology and preclinical safety studies (acute, subchronic, chronic, genotoxic, carcinogenic, reproductive and developmental toxicity, and toxicokinetics) in compliance with testing guidelines for regulatory health effects and Good Laboratory Practice (GLP) standards. His specialty area of expertise is inhalation toxicology.