Additional Capabilities

Necropsy and Histopathology

The Hamner has a full service necropsy and histopathology facility, primarily used to support internal research projects and programs.  These laboratories (necropsy, histology, and image analysis) are fully computerized and interfaced with The Hamner’s GLP-compliant Instem Provantis™ data collection system.  Pathology services are provided through a contract service provider located locally in Research Triangle Park, NC.  Our experienced pathology service partners provide animal necropsy prosectors, histology services, and histopathology evaluations as needed.  The histology laboratory has the capability for routine paraffin, plastic and frozen sectioning. Slide staining includes a full range of routine and special stains as well as enzyme histochemistry, immunocytochemistry and autoradiography. Specialized equipment consists of three automated microtomes, two automated research cryostats, an automated immunostainer, and a laser capture microscope.  The laboratory has light and digital gross and microscopic photography capability.  Full transmission and scanning electron microscopy capability is also available.

• Routine and perfusion fixation

• Routine and specialized tissue sectioning

• Immunohistochemistry (e.g., BrdU)

• Assay development and validation services

Microscopy and Flow Cytometry

• Confocal, laser-microdissection, and fluorescence microscopy

• BD FACSCanto II HTS

• Guava PC

• Bio-Plex protein array system

• FCS Express 4.0

Transgenic Rodent Facility

• Specialized breeding and management of rodent colonies

Quality Assurance

• Established QA/QC programs for GLP compliance

Human Health Risk Assessment

• PB/PK and PB/PD modeling

• Biomonitoring

• Tissue response modeling

• Systems biology approach