Scientists

Jeffry Schroeter

Jeffrey Schroeter

Education

B.S., mathematics, James Madison University, 1991.
Ph.D., applied mathematics, North Carolina State University, 1998.
Postdoctoral training, Curriculum in Toxicology, University of North Carolina at Chapel Hill, 1999-2002.
Postdoctoral training, Division of Computational Biology, CIIT Centers for Health Research, Research Triangle Park, North Carolina, 2002-2004.

Research

My research involves the development and application of computational fluid dynamics (CFD) models to study airflow, gas uptake, and particle deposition in human nasal passages. Current research efforts are focused on determining the regional deposition of inhaled particles for toxicological and pharmaceutical studies. The natural filtering properties of the upper respiratory tract allow particles entrained in the inspired air to collect in the nose. We are studying how this filtering mechanism can be advantageously used for the delivery of inhaled drugs, where therapeutic effect is influenced by deposition location.

Selected Publications

Schroeter, J. D., Kimbell, J. S., Bonner, A. M., Roberts, K. C., Andersen, M. E., and Dorman, D. C. (2006). Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats. Toxicol. Sci. 90, 198-207.

Schroeter, J. D., Pritchard, J. N., Hwang, D., and Martonen, T. B. (2005). Airway identification within planar gamma camera images using computer models of lung morphology. Pharmacol. Res. 22, 1692-1699.

Kimbell, J. S., Schroeter, J. D., Asgharian, B., Wong, B. A., Segal, R. A., Dickens, C. J., Southall, J. P., and Miller, F. J. (2004). Optimization of nasal delivery devices using computational models. Respiratory Drug Delivery IX Proceedings 1, 233-238.

Martonen, T. B. and Schroeter, J. D. (2003). Risk assessment dosimetry model for inhaled particulate matter: I. human subjects. Toxicol. Lett. 138, 119-132.

Martonen, T. B. and Schroeter, J. D. (2003). Risk assessment dosimetry model for inhaled particulate matter: II. laboratory surrogates (rat). Toxicol. Lett. 138, 133-142.

Martonen, T. B., Fleming J. S., Schroeter, J. D., Conway, J., and Hwang, D. (2003). In silico modeling of asthma. Adv. Drug Deliv. Rev. 55, 830-849.

Crowder, T. M., Rosati, J. A., Schroeter, J. D., Hickey, A. J., and Martonen, T. B. (2002). Fundamental effects of particle morphology on lung delivery: predictions of Stokes' law and the particular relevance to dry powder inhaler formulation and development. Pharm. Res. 19, 239-245.

Musante, C. J., Schroeter, J. D., Rosati, J. A., Crawford, T. M., Hickey, A. J., and Martonen, T. B. (2002). Factors affecting the deposition of inhaled porous drug particles. J. Pharm. Sci. 91, 1590-1600.

Schroeter, J. D., Fleming, J. S., Hwang, D., and Martonen, T. B. (2002). A computer model of lung morphology to analyze SPECT images. Comp. Med. Imag. Graph. 26, 237-246.

Ito, K. and Schroeter, J. D. (2001). Reduced order feedback synthesis for viscous incompressible flows. Math. Comp. Model. 33, 173-192.

Katz, I. M., Schroeter, J. D., and Martonen, T. B. (2001). Factors affecting the deposition of aerosolized insulin. Diabetes Tech. Ther. 3, 387-397.

Schroeter, J. D., Musante, C. J., Hwang, D., Burton, R., Guilmette, R., and Martonen, T. B. (2001). Hygroscopic growth and deposition of inhaled secondary cigarette smoke in human nasal pathways. Aerosol Sci. Technol. 34, 1-7.

Spencer, R. M., Schroeter, J. D., and Martonen, T. B. (2001). Computer simulations of lung airway structures using data-driven surface modeling techniques. Comp. Bio. Med. 31, 499-511.

Martonen, T. B., Schroeter, J. D., Hwang, D., Fleming, J. S., and Conway, J. H. (2000). Human lung morphology models for particle deposition studies. Inhal. Toxicol. 12, 109-121.