Scientists

Owen Moss

Owen Moss

Education

B.S., physics, New Mexico State University, Las Cruces, New Mexico, 1965.
M.S., radiation biology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, 1969.
Ph.D., inhalation toxicology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, 1976.
Diplomat, AMA Management Course, American Management Association, 1995.

Research

My current research interests focus on mechanisms that relate particles and biomarkers of inhaled particles to human health. This interest in the response of cells, tissues, and organs to particles is a natural extension of the application of aerosol physics toward a better understanding of inhalation dose-response relationships.

Selected Publications

Moss, O. R. (2007). Insights into the health effects of nanoparticles: Why numbers matter. Int. J. Nanotechnol. In press.

Moss, O. R. and Oldham, M. J. (2006). Dosimetry counts: Molecular hypersensitivity may not drive pulmonary hyperresponsiveness. J. Aerosol Med. 19(4), 555-564.

Moss, O. R. and Wong, V. A. (2006). When nanoparticles get in the way: Impact of projected area on in vivo and in vitro macrophage function. Inhal. Toxicol. 18, 711-716.

Moss, O. R., James, R. A., and Asgharian, B. (2006). Influence of exhaled air on inhalation exposure delivered through a directed flow nose only exposure system. Inhal. Toxicol. 18(1), 45-51.

White, D. C., Geyer, R., Cantu, J., Jo, S-C., Peacock, A. D., Saxton, A. M., Mani, S., Jett, M., and Moss, O. R. (2005). Feasibility of assessment of regulatory lipids in breath condensate as potential presymptomatic harbingers of pulmonary pathobiology. J. Microbiol. Methods. 62(3), 293-302.

Jackman, J. and Moss, O. (2004.) Mass spectrometry of breath for the diagnosis of infection and exposure. Johns Hopkins University APL (Applied Physics Laboratory) Technical Digest, 25, 6-13.

Bermudez, E., Mangum, J. B., Moss, O. R., Wong, B. A., and Everitt, J. I. (2003). Pleural dosimetry and pathobiological responses in rats and hamsters exposed subchronically to MMVF 10a fiberglass. Toxicol. Sci., 74, 165-173.

DeLorme, M. P. and Moss, O. R. (2002). Pulmonary function assessment by whole-body plethysmography in restrained versus unrestrained mice. J. Pharmacol. Toxicol. Methods 47, 1-10.

Vitarella, D., Moss, O., and Dorman, D. C. (2000). Pulmonary clearance of manganese phosphate, manganese sulfate, and manganese tetraoxide by CD rats following intratracheal instillation. Inhal. Toxicol. 12, 941-957.

Vitarella, D., Wong, B. A., Moss, O. R., and Dorman, D. C. (2000). Pharmacokinetics of inhaled manganese phosphate in male Sprague-Dawley rats following subacute (14-day) exposure. Toxicol. Appl. Pharmacol. 163, 279-285.

Gelzleichter, T. R., Bermudez, E., Mangum, J. B., Wong, B. A., Janszen, D. B., Moss, O. R., and Everitt, J. I. (1999). Comparison of pulmonary and pleural responses of rats and hamsters to inhaled refractory ceramic fibers. Toxicol. Sci. 49, 93-101.

Everitt, J. I., Gelzleichter, T. R., Bermudez, E., Mangum, J. B., Wong, B. A., Janszen, D. B., and Moss, O. R. (1997). Comparison of pleural responses of rats and hamsters to subchronic inhalation of refractory ceramic fibers. Environ. Health Perspect. 104 (Supplement 5), 1209-1213.

Han, R. and Moss, O. R. (1997). Flow visualization inside a water model virtual impactor. J. Aerosol Sci. 28, 1005-1014.

King-Herbert, A. P., Hesterberg, T. W., Thevenaz, P. H., Hamme, T. E., Moss, O. R., Janszen, D. B., and Everitt, J. I. (1997). Effects of immobilization restraint on Syrian golden hamsters. Lab. Anim. Sci. 47, 362-366.

Gelzleichter, T. R., Bermudez, E., Mangum, J. B., Wong, B. A., Everitt, J. I., and Moss, O. R. (1996). Pulmonary and pleural responses in Fischer 344 rats following short-term inhalation of a synthetic vitreous fiber. I. Quantitation of pleural fiber burdens. Fundam. Appl. Toxicol. 30, 31-38.

Gelzleichter, T. R., Bermudez, E., Mangum, J. B., Wong, B. A., Moss, O. R., and Everitt, J. I. (1996). Pulmonary and pleural responses in Fischer 344 rats following short-term inhalation of a carcinogenic synthetic vitreous fiber. II. Pathobiologic responses. Fundam. Appl. Toxicol. 30, 39-46.

Han, R. J., Moss, O. R., and Wong, B. A. (1996). Derivation and application of an analytical solution of the mass transfer equation to the case of forced convective flow around a cylindrical and a spherical particle with fluid surface properties. J. Aerosol Sci. 27, 235-247.

Han, R. J., Moss, O. R., and Wong, B. A. (1996). Dielectric force calculation for a cylindrical fiber of finite length by the energy displacement method. Aerosol Sci. Technol. 25,174-184.

Leavens, T. L., Moss, O. R., and Bond, J. A. (1996). Dynamic inhalation system for individual whole-body exposure of mice to volatile organic chemicals. Inhal. Toxicol. 8, 655-677.

Leavens, T. L., Moss, O. R., Turner, M. J., Janszen, D. B., and Bond, J. A. (1996). Metabolic interactions of 1,3-butadiene and styrene in male B6C3F1 mice. Toxicol. Appl. Pharmacol. 141, 628-636.

Owens, J. G., James, R. A., Moss, O. R., Morgan, K. T., Bowman, J. R., Struve, M. F., and Dorman, D. C. (1996). Design and evaluation of an olfactometer for the assessment of 3-methylindole-induced hyposmia. Fundam. Appl. Toxicol. 33, 66-70.

Han, R. J., Moss, O. R., and Wong, B. A. (1994). Airborne fiber separation by electrophoresis and dielectrophoresis: theory and design considerations. Aerosol Sci. Technol. 21, 241-258.

Dorman, D. C., Moss, O. R., Farris, G. M., Janszen, D., Bond, J. A., and Medinsky, M. A. (1994). Pharmacokinetics of inhaled 14C-methanol and methanol-derived 14C-formate in normal and folate-deficient cynomolgus monkeys. Toxicol. Appl. Pharmacol. 128, 229-232.

Asgharian, B. and Moss, O. R. (1992). Particle suspension in a rotating drum chamber when the influence of gravity and rotation are both significant. Aerosol Sci. Technol. 17, 263-277.