Scientists

Qiang Zhang

Qiang Zhang

Education

M.D., Harbin Medical University, People's Republic of China, 1995.
Ph.D., physiology and neurobiology, University of Connecticut, 2003.
Postdoctoral training, Division of Computational Biology, CIIT Centers for Health Research, Research Triangle Park, North Carolina, 2003-2006.

Research

My research is currently focused in two areas. One is adaptive cellular response to biological stressors. Control theory is used to study the steady-state dose response curves for intracellular species including transcription factors, anti-stress genes, and controlled variables. The other research area is focused on the terminal differentiation of B cells in response to antigens and how the environmental pollutant dioxin interferes with this process. Both deterministic and stochastic approaches are employed for these research topics.

Publications

Pi J., Zhang Q., Woods C.G., Wong V., Collins S., and Andersen M.E. (2008). Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid. Toxicology and Applied Pharmacology. 226(3): 236-243.

Zhang Q., Pi J., Woods C.G., Jarabek A.M., Clewell H.J. III, and Andersen M.E. (2008). Hormesis and Adaptive Cellular Control Systems. Dose-Response. 6(2):196-208.

Li, L., Heber, S., Andersen, M. E., and Zhang, Q. (2007). Non-monotonic dose response relationship in steroid hormone receptor-mediated gene expression. J. Mol. Endocrinol. 38(5), 569-585.

Pi J., Bai Y., Zhang Q., Wong V., Floering L.M., Daniel K., Reece J.M., Deeney J.T., Andersen M.E., Corkey B.E., and Collins S. (2007). Reactive Oxygen Species as a Signal in Glucose-stimulated Insulin Secretion. Diabetes. 56(7): 1783-1791.

Zhang, Q. and Andersen, M. E. (2007). Dose response relationship in anti-stress gene regulatory networks. PLoS Comput. Biol. 3(3), e24.

Zhang, Q., Andersen, M. E., and Conolly, R. B. (2006). Binary gene induction and protein expression in individual cells. Theor. Biol. Med. Model. 3(1), 18.

Zhang, Q. and Gallo. R. V. (2003). Presence of kappa-opioid tone at the onset of the ovulatory luteinizing hormone surge in the proestrous rat. Brain Res. 980, 135-139.

Zhang, Q., McCoy, J. M., and Gallo, R. V. (2002). Further studies on possible dynorphin involvement in the ovulatory luteinizing hormone surge in the proestrous rat. Endocrine 18, 231-238.

Zhang, Q. and Gallo, R. V. (2002). The effect of prodynorphin-derived opioid peptides on the ovulatory luteinizing hormone surge in the proestrous rat. Endocrine 18, 27-32.