Scientists

Yu-Mei (Cecilia) Tan

Yu-Mei (Cecilia) Tan

Education

B.S., environmental engineering, National Cheng Kung University, Taiwan, 1995.
M.S., environmental sciences and engineering, Harvard University, 1997.
Ph.D., environmental sciences and engineering, University of North Carolina at Chapel Hill, 2001.
Postdoctoral training, Division of Biomathematics and Physical Sciences, CIIT Centers for Health Research, Research Triangle Park, North Carolina, 2001-2003.

Research

My research interest is developing mathematical models to describe (1) human exposure to environmental or occupational chemicals; (2) the pharmacokinetics of these chemicals inside the human body; and (3) the pharmocodynamics of these chemicals at molecular levels. The focus of my current work is on the use of these models in cancer and non-cancer risk assessment and interpreting biomonitoring data.

Selected Publications

Tan, Y.-M., Liao, K. H., and Clewell, H. J. (2006). Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling. J. Expo. Sci. Environ. Epidemiol. doi:10.1038/sj.jes.7500540.

Tan, Y.-M., Liao, K. H., Conolly R. B., Blount, B. C., Mason, A. M., and Clewell, H. J. (2006). Use of a physiologically based pharmacokinetic model to evaluate biomonitoring data of human chloroform exposure. J. Toxicol. Environ. Health 69(18), 1727-1756.

Tan, Y.-M., Butterworth, B. E., Gargas, M. L., and Conolly, R. B. (2003). Biologically motivated computational modeling of chloroform cytolethality and regenerative cellular proliferation. Toxicol. Sci. 75, 192-200.

Tan, Y.-M. and Flynn, M. R. (2002). Methods for estimating the transfer efficiency of a compressed air spray gun. Appl. Occup. Environ. Hyg. 17, 39-46.

Tan, Y.-M., Flynn, M. R., and Buller, T. S. (2002). A field evaluation of the impact of transfer efficiency on worker exposure during spray painting. Ann. Occup. Hyg. 46, 103-112.

Tan, Y.-M. and Flynn, M. R. (2000). Experimental evaluation of a mathematical model for predicting transfer efficiency of a high volume-low pressure air spray gun. Appl. Occup. Environ. Hyg. 15, 785-793.

Tan, Y.-M., DiBerardinis, L., and Smith, T. (1999). Exposure assessment of laboratory students. Appl. Occup. Environ. Hyg. 14, 530-538.