Darol E. Dodd, Ph.D., DABT

Senior Research Toxicologist and Manager, Research Support Services

ddodd@thehamner.org
Click to view full bio

Education

B.A., Biology, University of Kansas, Lawrence, Kansas, 1971.

Ph.D., Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, 1978.

Postdoctoral training, Chemical Industry Institute of Technology, 1978-1980.

Diplomate, American Board of Toxicology.

Research

My research interests include the design and conduct of whole-animal toxicology and preclinical safety studies used to support health risk assessments, the setting of exposure standards, and the development of pharmaceuticals for IND applications. These studies vary in frequency of dosing (acute, subacute, subchronic, and chronic), route of administration (inhalation, oral, dermal, peritoneal), endpoints (general toxicity, reproductive and developmental toxicity, genotoxicity, and tumorgenicity), and species (mice, rats, guinea pigs). I am particularly interested in inhalation toxicity studies, because of the technical challenges in generating and characterizing different test material atmospheres (vapor, aerosol, particles). The generation and analysis of methyl isocyanate vapor for investigating responses in laboratory animals is an example. I've evaluated a wide range of test chemicals and products, most recently, alternatives of ozone-depleting substances. In a majority of cases, studies are conducted according to regulatory health effects testing guidelines and under good laboratory practice standards (GLPs). Following completion of a series of toxicity studies, I prepare health hazard reports that are of value to regulatory agencies in setting occupational exposure levels (OEL) or reference dose/concentration values (RfD/RfC).

Selected Publications - click to view

Dodd, D.E., L.J. Pluta, M.A. Sochaski, D.A. Banas, and R.S. Thomas.  Subchronic hepatotoxicity evaluation of bromobenzene in Fischer 344 rats.  Accepted Jan 2012 by J. Appl. Toxicol.

Dodd, D.E., L.J. Pluta, M.A. Sochaski, K.A. Funk, and R.S. Thomas.  Subchronic hepatotoxicity evaluation of 1,2,4-tribromobenzene in Sprague Dawley rats.  Accepted Jan 2012 by Int. J. Toxicol.

Dodd, D.E., B.A. Wong, E.A. Gross, and R.A. Miller.  2012.  Nasal epithelial lesions in F344 rats following a 90-day inhalation exposure to naphthalene.  Inhalation Toxicology, online  DOI:10.3109/08958378.2011.636086 (ISSN 0895-8378 print/ISSN 1091-7691 online)

Dodd, D., G. Willson, H. Parkinson, and E. Bermudez.  2012.  Two-year drinking water carcinogenicity study of methyl tertiary-butyl ether (MTBE) in Wistar rats.   J. Appl. Toxicol. online DOI 10.1002/jat.1776

E. Bermudez, G. Willson, H. Parkinson, and D. Dodd.  2011.  Toxicity of methyl tertiary-butyl ether (MTBE) following exposure of Wistar rats for 13 weeks or one year via drinking water.  J. Appl. Toxicol., online DOI 10.1002/jat.1674

Meng, F., Y. Wang, M.B. Myers, B.A. Wong, E.A. Gross, H.J. Clewell III, D.E. Dodd, and B.L. Parsons.  2011.  p53 codon 271 CGT to CAT mutant fraction does not increase in nasal respiratory and olfactory epithelia of rats exposed to inhaled naphthalene.  Mutation Research/Genetic Toxicology and Environmental Mutagenesis, on-line  DOI:10.1016/j.mrgentox.2011.02.004.

Andersen, M.E., H.J. Clewell, III, E. Bermudez, D.E. Dodd, G.A. Willson, J.L. Campbell, and R.S. Thomas.  2010.  Formaldehyde: integrating dosimetry, cytotoxicity and genomics to understand dose-dependent transitions for an endogenous compound.  Toxicol. Sci. 118:716-731.

Mattie, D.R., G.M. Hoffman, L. Narayanan, T.R. Sterner, M.J. Wagner, and D.E. Dodd.  2010. A 13-week nose-only inhalation toxicity study for perfluoro-n-butyl iodide (PFBI) in rats with recommended occupational exposure levels. Inhalation Toxicol. 22:847-860.

Dodd, D.E., EA Gross, R.A. Miller, and B.A. Wong.  2010.  Nasal olfactory epithelial lesions in F344 and SD rats following 1- and 5-day inhalation exposure to naphthalene vapor.  Int. J. Toxicol.  29:175-184.

Ryman-Rasmussen, J.P., M.F. Cesta, AR. Brody, J.K. Shipley-Phillips, J.I. Everitt, E.W. Tewksbury, O.R. Moss, B.A Wong, D.E. Dodd, M.E. Andersen, and J.C. Bonner.  2009. Inhaled carbon nanotubes reach the subpleural tissue in mice.  Nature Nanotech published online: DOI: 10.1038/NNANO.2009.305.

Dodd, D. E. and Brock, W. J. (2006). Chapter 32. Fluorocarbon alternatives - Methodologies for special studies and results. In Inhalation Toxicology, Second Edition (Salem, H. and Katz, S. A., editors), pp. 825-850. CRC Press, Boca Raton.

Dodd, D. E., Hoffmann, G. M., and Hardy, C. J. (2004). Perfluoro-n-butyl iodide: acute toxicity, subchronic toxicity and genotoxicity evaluations. Int. J. Toxicol. 23, 249-258.

York, R. G., Barnett Jr., J., Brown, W. R., Garman, R. H., Mattie, D. R., and Dodd, D. (2004). A rat neurodevelopmental evaluation of offspring, including evaluation of adult and neonatal thyroid, from mothers treated with ammonium perchlorate in drinking water. Int. J. Toxicol. 23, 191-214.

Geiss, K. T., Frazier, J. M., and Dodd, D. E. (2002). Toxicity screening of halogenated aliphatics using a novel in vitro volatile chemical exposure system. In Proceedings of the HOTWC-2002 12th Halon Options Technical Working Conference, April 20-May 2 2002, Albuquerque, NM (Gann, R. G. and Reneke, P. A., editors), pp. 1-10. NIST Special Publication 984. http://www.bfrl.nist.gov/866/HOTWC.

Dodd, D., Ivankoe, M., Ferlazzo, P., and Niles, J. (2001). PAX-21 reduced sensitivity energetics toxicology. In Proceedings of 2001 Insensitive Munitions and Energetic Materials Technology Symposium, held October 8-11, 2001, NDIA/Club Murat, Bordeaux, France, pp. 253-268.

Siglin, J. C., Mattie, D. R., Dodd, D. E., Hildebrandt, P. K., and Baker, W. H. (2000). A 90-day drinking water toxicity study in rats of the environmental contaminant ammonium perchlorate. Toxicol. Sci. 57, 61-74.

Dodd, D. E., Leahy, H. F., Feldmann, M. L., English, J. H., and Vinegar, A. (1999). Reproductive toxicity screen of trifluoroiodomethane (CF3I) in Sprague-Dawley rats. Inhal. Toxicol. 11, 1041-1055.

Dodd, D. E. and Vinegar, A. (1999). Toxicity data comparisons of CF3I with currently used fire-extinguishing agents and refrigerants of interest to the military. In Proceedings Halon Options Technical Working Conference, April 27-29, 1999, Albuquerque, NM, pp. 233-241. NIST Special Publication 984 http://www.bfrl.nist.gov/866/HOTWC/HOTWC2003/pubs/R9902724.pdf.

Tyl, R. W., Fisher, L. D., Dodd, D. E., Pritts, I. M., Kubena, M. F., Losco, P. E., Troup, C. M., Lyon, P. P., and Landry, T. D. (1999). Developmental toxicity evaluation of inhaled toluene diisocyanate vapor in CD rats. Toxicol. Sci. 52, 248-257.

Tyl, R. W., Neeper-Bradley, T. L., Fisher, L. C., Dodd, D. E., Pritts, I. M., Losco, P. E., Lyon, J. P., and Landry, T. D. (1999). Two-generation reproductive toxicity study of inhaled toluene diisocyanate vapor in CD rats. Toxicol. Sci. 52, 258-268.

Dodd, D. E. and Vinegar, A. (1998). Cardiac sensitization testing of the halon replacement candidates trifluoroiodomethane (CF3I) and 1,1,2,2,3,3,3-heptafluoro-1-iodopropane (C3F7I). Drug Chem. Toxicol. 21, 137-149.

Additional Scientists