Kyoungju Choi, Ph.D.
Research Scientist
Education
B.S. Food Science, Seoul Woman’s University, Seoul, South Korea, 1992.
M.S. Food Fermentation Chemistry, Kon Kuk University, Seoul, South Korea, 1995.
Ph.D. Environmental Toxicology, immunology & biotechnology, North Carolina State University, Raleigh, North Carolina, 2004.
Postdoctoral training with emphasis on human metabolism of environmental chemicals and identification of human population at risk in the laboratory of Dr. Ernest Hodgson, North Carolina State University, Raleigh, North Carolina, 2005-2008.
Research
My research of interest involves the development of in vitro system to study xenobiotic metabolism of humans and animals using biochemical technology and their application to safety and risk assessment of environmental chemicals. The central goal of these efforts is to develop reliable methods for in vitro to in vivo extrapolation using human biological values and reducing our dependence on laboratory animals in toxicity testing. Current research efforts are focused on the qualitative/quantitative measurement of all of the phase I and phase II metabolic products of phthalate and parabens with varying tissue fractions of human and laboratory animal, recombinant drug metabolizing enzymes (DMEs) and primary cell systems.
Selected Publications - click to view
Kyoungju Choi, Hyun Joo, Jerry L. Campbell, Rebecca A. Clewell, Melvin E. Andersen and Harvey J. Clewell III. In vitrometabolism of Di(2-ethylhexyl) phthalate (DEHP) by varying organs and cytochrome P450s of human and rat. Toxicology in Vitro. (In preparation).
Joo, H., Choi, K. and Hodgson E. 2010. Human metabolism of atrazine. Pest. Biochem. Physiol. 98, 73-79.
Joo, H., Choi, K., Rose R.L. and Hodgson E. 2007. Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos. J. Biochem. Mol. Toxicol. 21, 76-80.
Choi, K., Joo, H., Rose R.L. and Hodgson E. 2006. Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes. J. Biochem. Mol. Toxicol. 20, 279-291.
Choi. K., Mac, J.L., Harms, C. and Lehman D.W. 2007. Acute hypoxia-reperfusion triggers immunocompromise in Tilapia (Oreochromis niloticus). J Aquat. Anim. Health. 19, 128- 140.
Additional Scientists
- Alison H. Harrill, Ph.D.
- Barbara A. Wetmore, Ph.D.
- Brett A. Howell, Ph.D.
- Darol E. Dodd, Ph.D., DABT
- Edward L. LeCluyse, Ph.D.
- Harvey J. Clewell III, Ph.D., DABT
- Jeffrey L. Woodhead, Ph.D.
- Jerry Campbell, Jr., Ph.D.
- Jingbo Pi, M.D., Ph.D.
- Joshua A. Harrill, Ph.D.
- Kyoungju Choi, Ph.D.
- Melvin E. Andersen, Ph.D., DABT, CIH
- Miyoung Yoon, Ph.D.
- O. Joe Trask, B.S.
- Paul B. Watkins, M.D.
- Qiang Zhang, M.D., Ph.D.
- Rebecca A. Clewell, Ph.D.
- Russell S. Thomas, Ph.D.
- Sudin Bhattacharya, Ph.D.
- Yuching Yang, Ph.D.