Melvin E. Andersen, Ph.D., DABT, CIH

Director, Institute for Chemical Safety Sciences
Chief Science Officer
Charles E. Hamner, Jr. Distinguished Fellow
Senior Investigator

mandersen@thehamner.org
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Education

Sc.B., chemistry, Brown University, Providence, Rhode Island, 1967.

Ph.D., biochemistry and molecular biology, Cornell University, Ithaca, New York, 1971.

Certified Industrial Hygienist, American Board of Industrial Hygiene.

Diplomate, American Board of Toxicology.

Research

My research focuses on developing biologically based models for the uptake, distribution, metabolism, and biological effects of drugs and chemicals and their application to safety assessments and quantitative health risk assessments. In recent years, my research emphasis has been on developing mathematical descriptions of control of genetic circuitry and the dose-response and risk-assessment implications of these control processes.

Selected Publications - click to view

Zhang, Q. and Andersen, ME. (2007). Dose response relationship in anti-stress gene regulatory networks. PLoS Comput Biol. 2007 Mar 2; 3(3):e24. Epub 2006 Dec 22. Best Biological Modeling Paper for 2007 presented by the Biological Modeling Specialty Section of the Society of Toxicology, 2008.

Thomas, R.S., Allen, B.C., Nong, A., Yang, L., Bermudez, E., Clewell, H.J., III, and Andersen, M.E. (2007). A method to integrate benchmark dose estimate with genomic data to assess the functional effects of chemical exposure. Toxicol. Sci., 98, 240-248. Best Risk Assessment Paper 2007 presented by the Risk Assessment Specialty Section of the Society of Toxicology, 2008.

Andersen, M.E., Krewski, D., Mantus, E., and Zeise, L. (2008). Toxicity Testing in the 21st Century.
www.alttox.org/ttrc/overarching-challenges/way-forward/andersen/

Clewell, H.J., III, Tan, Y.M., Campbell, J.L., and Andersen, M.E. (2008). Quantitative Interpretation of Human Biomonitoring Data. Toxicol. Appl. Pharrmacol., 2008 May 4 epub PMID: 18589468.

Reddy, M.B., Domoradzki, J., Dobrev, I.D., Jovanic, M.L., Crofoot, S., McNett, D.A., Tobin, J.M., Utell, M.J., Morrow, P.E., Plotzke, K.P., and Andersen, M.E. (2008). Physiological modeling of the inhalation kinetics of decamethylcyclopentasiloxane (D5) in rats and humans. Toxicol. Sci., 2008 Jun 26. PMID: 18583370

McLanahan, E.D., Andersen, M.E. and Fisher, J.W. (2008). Biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat: evaluation of iodide deficiency. Tox. Sci., 102, 241-253.

Andersen, M.E., Reddy, M.B., and Plotzke, K.P. (2008). Are Highly Lipophilic Volatile Organic Compounds Expected to Bioaccumulate on Repeated Exposures? Toxicol. Ltrs., 179, 85-92.

Blaauboer, B. and Andersen, M.E. (2007). The need for a new toxicity testing paradigm to implement REACH or any other large scale testing initiative. Archiv. Toxicol., 81, 385-387.

Zhu, L., Pi, J., Wachi, S., Andersen, M.E., Wu, R. and Chen, Y. (2007). Identification of Nrf2-dependent airway epithelial adaptive responses to pro-inflammatory oxidant hypochlorous acid (HOCl) challenge by transcriptional profiling. American Journal of Physiology, Lung Cellular and Molecular Physiology, 294, L469-477.

Pi, J., Zhang, Q., Woods, C.G., Wong, V., Collins, S., and Andersen, M.E. (2007). Hypochlorous acid activates Nrf2-mediated antioxidant response signaling in macrophages. Toxicol. Appl. Pharmacol., 226, 236-243.

Nong, A., Teeguarden, J.G., Clewell, H.J., III, Dorman, D.C. and Andersen, M.E. (2008). Pharmacokinetic modeling of Manganese. IV. Assessing factors that contribute to brain accumulation during inhalation exposures, J. Toxicol. Environ. Health: Part A, 71, 413-426

Andersen, M.E., Clewell, H.J., III, Bermudez, E., Wilson, G.A., and Thomas, R.S. (2008). Genomic signatures and dose dependent transitions in nasal epithelial responses to inhaled formaldehyde in rats. Toxicol. Sci., 2008 May21 epbub.

Clewell, R.A., Kremer, J.J., Williams, C.C., Andersen, M.E., and Borghoff, S.J. (2007). "Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: Evaluation with a PBPK model". Sci., 103, 241-259.

Pi, J., Bai, Y., Zhang, Q., Wong, V., Floering, L. M., Daniel, K., Reece, J. M., Deeney, J. T., Andersen, M. E., Corkey, B. E., and Collins, S. (2007). Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes. In press.

Andersen, M. E. (2007). Mode of action and tissue dosimetry considerations in interspecies extrapolation. Hum. Ecol. Risk Assess. 13, 101-110.


Leavens, T. L., Rao, D., Andersen, M. E., and Dorman, D.C. (2007). Evaluating transport of manganese from olfactory mucosa to striatum by pharmacokinetic modeling. Toxicol. Sci. 97(2), 265–278.


Li, L., Zhang, Q. and Andersen, M. E. (2007). Non-monotonic dose response relationship in steroid hormone-receptor mediated gene expression. J. Mol. Endocrinol. 38, 569-585.


Andersen, M. E., Clewell, H. J., III, Tan, Y. M., Butenhoff, J. L., and Olsen, G. W. (2006). Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys – probing the determinants of long plasma half-lives. Toxicology 227, 156-164.


Andersen, M. E., Lutz, R. W., Liao, K. H., and Lutz, W. K. (2006). Dose-incidence modeling: Consequences of linking quantal measures of response to depletion of critical tissue targets. Toxicol. Sci. 89, 331-337.


Dorman, D. C., Struve, M. E., Clewell, H. J., III, and Andersen, M. E. (2006) Application of pharmacokinetic data to the risk assessment of inhaled manganese. Neurotoxicology 27, 752-764.


Schroeter, J. D., Kimbell, J. S., Bonner, A. M., Roberts, K. C., Andersen, M. E., and Dorman, D. C. (2006). Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats. Toxicol. Sci. 90, 198-207.


Lutz, W. K., Lutz, R. W. and Andersen, M. E. (2006). Dose-incidence relationships derived from superposition of individual susceptibility on mechanism-based dose responses for biological effects. Toxicol. Sci. 90, 33-38.


Zhang, Q., Andersen, M. E., and Conolly, R. B. (2006). Binary gene induction and protein expression in individual cells. Theor. Biol. Med. Model. 3(1), 18.


Andersen, M. E., Dennison, J. E., Thomas, R. S., and Conolly, R. B. (2005). New directions in incidence-dose modeling. Trends Biotechnol. 23, 122-127.


Andersen, M. E., Thomas, R. S., Gaido, K. W., and Conolly, R. B. (2005). Dose-response modeling in reproductive toxicology in the systems biology era. Reprod. Toxicol. 19, 327-337.


Reddy, M., Yang, R. S., Andersen, M. E., and Clewell, H. J., III (editors). (2005). Physiologically Based Pharmacokinetic Modeling: Science and Applications, 440 pp. John Wiley & Sons, Inc., Hoboken, NJ.


Andersen, M. E. and Dennison, J. E. (2004). Mechanistic approaches for mixture risk assessments—present capabilities with simple mixtures and future directions. Environ. Toxicol. Pharmacol. 16, 1-11.


Broccardo, C. J., Billings, R. E, Chubb, L. S., Andersen, M. E., and Hanneman, W. H. (2004). Single cell analysis of switch-like induction of CYP1A1 in liver cell lines. Toxicol. Sci. 78, 287-294.


Clewell, H. J., III and Andersen, M. E. (2004). Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene. Crit. Rev. Toxicol. 34, 385-445.


French, C. T., Hanneman, W. H., Chubb, L. S., Billings, R. E., and Andersen, M. E. (2004). Induction of CYP1A1 in primary rat hepatocytes by 3,3-,4,4-,5-pentachlorobiphenyl: evidence for a switch circuit element. Toxicol. Sci. 78, 276-286.


McMullin, T. S., Andersen, M. E., Nagahara, A., Lund, T. D., Pak, T., Handa, R. J., and Hanneman, W. H. (2004). Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of LH in female Sprague-Dawley rats without changing estrogen receptor actions. Toxicol. Sci. e-pub, 2004 Mar 31.


Slikker Jr., W., Andersen, M. E., Bogdanffy, M. S., Bus, J. S., Cohen, S. D., Conolly, R. B., David, R. M., Doerrer, N. G., Dorman, D. C., Gaylor, D. W., Hattis, D., Rogers, J. M., Setzer, R. W., Swenberg, J. A., and Wallace, K. (2004). Dose-dependent transitions in mechanisms of toxicity. Toxicol. Appl. Pharmacol. 201, 203-225.


Reddy, M. B., Andersen, M. E., Morrow, P. E., Dobrev, I. D., Varaprath, S., Plotzke, K. P., and Utell, M. J. (2003). Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise. Toxicol. Sci. 72, 3-18.


Andersen, M. E. (2002). The use of quantitative histological and molecular data for risk assessment and Clewell, H. J., III, Andersen, M. E., and Barton, H. A. (2002). A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment. Environ. Health Perspect. 110, 85–93.


Sarangapani, R., Teeguarden, J., Plotzke, K. P., McKim Jr., J. M., and Andersen, M. E. (2002). Dose-response modeling of cytochrome P450 induction in rats by octamethylcyclotetrasiloxane in rats. Toxicol. Sci. 67,159–172.


Andersen, M. E. and Dennison, J. E. (2001). Mode of action and tissue dosimetry in current and future risk assessments. Sci. Total Environ. 274, 3–14.


Andersen, M. E. and Sarangapani, R. (2001). Physiologically based clearance/extraction models for compounds metabolized in the nose: an example with methyl methacrylate. Inhal. Toxicol. 13, 397–414.


Clewell, H. J., III, H. J., Barton, H. A., Maull, E. A., and Andersen, M. E. (2001). Under what conditions is trichloroethylene likely to be a human carcinogen? Human Environ. Risk Assess. 7, 687–716.

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