Technology & Development
Technology Transfer
Bioinformatics Software
BMDExpress is a Java application used to analyze dose-response data from microarray experiments. The program was designed to perform a stepwise analysis on microarray data that combines bench mark dose (BMD) calculations with gene ontology (GO) classification analysis. The combination provides dose estimates at which different cellular processes are altered at a defined increase in risk based on expression levels in the untreated controls. The fitting of the data to the statistical models (linear, 2° polynomial models, 3° polynomial, and power models) is performed using source code borrowed from the U.S. Environmental Protection Agency's BMDS software. For more information about the EPA's BMDS software, go to the EPA's NCEA web site.
For questions about BMDExpress, please contact Dr. Rusty Thomas or Dr. Longlong Yang.
Multiple Path Particle Dosimetry Model (MPPD v 2.0)
A Model for Human and Rat Airway Particle Dosimetry
Inventors and Developers
The multiple-path particle dosimetry (MPPD) model was developed jointly by The Hamner Institutes and the Dutch National Institute for Public Health and the Environment (RIVM). Members of The Hamner project team are O. T. Price and B. Asgharian. Members of the RIVM project team are F. R. Cassee and R. de Winter-Sorkina.
Applications
The MPPD model is a computational model that can be used for estimating human and rat airway particle dosimetry. The model is applicable to risk assessment, research, and education.
The MPPD model calculates the deposition and clearance of monodisperse and polydisperse aerosols in the respiratory tracts of rats and human adults and children (deposition only) for particles ranging in size from ultrafine (0.01 µm) to coarse (20 µm). The models are based on single-path and multiple-path methods for tracking air flow and calculating aerosol deposition in the lung. The single-path method calculates deposition in a typical path per airway generation, while the multiple-path method calculates particle deposition in all airways of the lung and provides lobar-specific and airway-specific information. Within each airway, deposition is calculated using theoretically derived efficiencies for deposition by diffusion, sedimentation, and impaction within the airway or airway bifurcation. Filtration of aerosols by the head is determined using empirical efficiency functions. The MPPD model includes calculations of particle clearance in the lung following deposition.
Eight tutorials are provided so that the user can learn to interact with the software.
References
Anjilvel, S. and Asgharian, B. (1995). A multiple-path model of particle deposition in the rat lung. Fundam. Appl. Toxicol. 28, 41-50.
National Institute for Public Health and the Environment (RIVM) (2002). Multiple Path Particle Dosimetry Model (MPPD v 1.0): A Model for Human and Rat Airway Particle Dosimetry. Bilthoven, The Netherlands. RIVA Report 650010030.
License Terms
The MPPD software is now available for download. To receive the MPPD software, please complete and submit our online registration form.
You will receive an e-mail with the link to the MPPD software downloads page. If you have any questions, please contact MPPD support
Copies of the MPPD software are also available on compact disk from:
Jeanne Galbo / The Hamner Institutes for Health Sciences
Telephone: 919-558-1389
Patent Status
None. A patent is not being pursued.