Translational Research
During the past five years, The Hamner has been successfully competing for NIH grants to conduct basic and translational research in the following areas:
Metabolic Disorders
- Hormonal regulation of metabolic networks in adipose tissue
- Mechanisms of unrestrained hepatic gluconeogenesis and insulin resistance associated with diabetes
- Roles of reactive oxygen species as putative signals mediating glucose-stimulated insulin secretion
Oncology
- National Cancer Institute supported program in pre-clinical efficacy testing of chemopreventive and therapeutic agents
- DNA cancer vaccine entering Phase II trials
- Evaluation of inhibitory RNAs as cancer therapeutics
Respiratory Disease
- Effects of cytokine signaling and inflammatory phenotypes on airway epithelial differentiation, remodeling, and innate defense
- Airway epithelial antiviral response in virus-induced disease exacerbation
Nanosafety
- Assessment of nanoparticle safety
- Development of nanoparticle delivery systems