Scientists
Brian A. Wong, Ph.D.
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Education
B.S., chemistry, Harvey Mudd College, Claremont, California, 1974.
M.S., environmental engineering science, California Institute of Technology, Pasadena, California, 1984.
Ph.D., environmental engineering science, California Institute of Technology, Pasadena, California, 1991.
Research
My research in inhalation toxicology focuses on the physical and engineering aspects of transporting materials into the respiratory system. One goal is advancing the engineering of inhalation exposure systems, including the development of specialized equipment for conducting inhalation studies and developing programming for the automation of exposure control and data collection. I have a special interest in the application of aerosol science technology to generate well-controlled and well-characterized atmospheres. Recently, we have been using these methods to study the deposition and retention of aerosols in the respiratory tract, especially to validate mathematical models under development at The Hamner.
Selected Publications
Kimbell, J. S., Segal, R. A., Asgharian, B., Wong, B. A., Schroeter, J. D., Southall, J. P., Dickens, C. J., Brace, G., Miller, F. J. (2007). Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages. J. Aerosol Med. 20, 59-74.
Wong, B. A. (2007). Inhalation exposure systems: Design, methods and operation. Toxicol. Pathol. 35, 3-14.
Dorman, D. C., Struve, M. F., Wong, B. A., Dye, J. A., and Robertson, I. D. (2006). Correlation of brain magnetic resonance imaging changes with pallidal manganese concentrations in rhesus monkeys following subchronic manganese inhalation. Toxicol. Sci. 92, 219-227.
Dorman, D. C., Struve, M. F., Marshall, M. W., Parkinson, C. U., James, R. A., and Wong, B. A. (2006). Tissue manganese concentrations in young male rhesus monkeys following subchronic manganese sulfate inhalation. Toxicol. Sci. 92, 201-210.
Dorman, D.C., Struve, M.F., Gross, E. A., Wong, B. A., and Howroyd, P. C. (2005). Sub-chronic inhalation of high concentrations of manganese sulfate induces lower airway pathology in rhesus monkeys. Respir. Res. 6, 121.
Kelly, J. T., Asgharian, B., and Wong, B. A. (2005). Inertial particle deposition in a monkey nasal mold with comparison to that in human nasal replicas. Inhal. Toxicol. 17, 823-830.
Dorman, D. C., McElveen, A. M., Marshall, M. W., Parkinson, C. U., James, R. A., Struve, M. F., and Wong, B. A. (2005). Maternal-fetal distribution of manganese in the rat following inhalation exposure to manganese sulfate. Neurotoxicology, 26, 625-632.
Dorman, D. C., McElveen, A. M., Marshall, M. W., Parkinson, C. U., James, R. A., Struve, M. F., and Wong, B. A. (2005). Tissue manganese concentrations in lactating rats and their offspring following combined in utero and lactation exposure to inhaled manganese sulfate. Toxicol. Sci. 84, 12-21.
Bermudez, E., Mangum, J. B., Wong, B. A., Asgharian, B., Hext, P. M., Warheit, D. B., and Everitt, J. I. (2004). Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol. Sci. 77, 347-357.
Kelly, J. T., Asgharian, B., Kimbell, J. S., and Wong, B. A. (2004). Particle deposition in human nasal airway replicas manufactured by different methods. Part I: Inertial regime particles. Aerosol Sci. Technol. 38, 1063-1071.
Kelly, J. T., Asgharian, B., Kimbell, J. S., and Wong, B. A. (2004). Particle deposition in human nasal airway replicas manufactured by different methods. Part II: Ultrafine particles. Aerosol Sci. Technol. 38, 1072-1079.
Recio, L., Donner, M., Abernethy, D., Pluta, L., Steen, A., Wong, B. A., James, A., Preston, R. J. (2004). In vivo mutagenecity and mutation spectrum in the bone marrow and testes of B6C3F1 lacI transgenic mice following inhalation exposure to ethylene oxide. Mutagenesis 19, 215-222.
Bermudez, E., Mangum, J. B., Moss, O. R., Wong, B. A., and Everitt, J. I. (2003). Pleural dosimetry and pathobiological responses in rats and hamsters exposed subchronically to MMVF 10a fiberglass. Toxicol. Sci. 74, 165-173.
Wong, B. A. (2003). Automated feedback control of an inhalation exposure system with discrete sampling intervals: testing, performance, and modeling. Inhal. Toxicol. 15, 729-743.
Rao, D. B., Wong, B. A., McManus, B. E., McElveen, A. M., James, A. R., and Dorman, D. C. (2003). Inhaled iron, unlike manganese, is not transported to the rat brain via the olfactory pathway. Toxicol. Appl. Pharmacol. 193, 116-126.
Bermudez, E., Mangum, J. B., Asgharian, B., Wong, B. A., Reverdy, E. E., Janszen, D. B., Hext, P. M., Warheit, D. B., and Everitt, J. I. (2002). Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. Toxicol. Sci. 70, 86-97.
Constan, A. A., Wong, B. A., Everitt, J. I., and Butterworth, B. E. (2002). Chloroform inhalation exposure conditions necessary to initiate liver toxicity in female B6C3F1 mice. Toxicol. Sci. 66, 201-208.
Dorman, D. C., Brenneman, K. A., McElveen, A., Lynch, S. E., Roberts, K. C., and Wong, B. A. (2002). Olfactory transport: a direct route of delivery of inhaled manganese phosphate to the rat brain. J. Toxicol. Environ. Health 65, 1493-1511.
Borghoff, S. J., Prescott, J. S., Janszen, D. B., Wong, B. A., and Everitt, J. I. (2001). a2u globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats. Toxicol. Sci. 61, 176-186.
Dorman, D. C., Struve, M. F., and Wong, B. A. (2001). Brain manganese concentrations in rats following manganese tetroxide inhalation are unaffected by dietary manganese intake. Neurotoxicology 77, 1-11.
Dorman, D. C., Struve, M. F., James, R. A., Marshall, M. W., Parkinson, C. U., and Wong, B. A. (2001). Influence of particle solubility on the delivery of inhaled manganese to the rat brain: manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14-day) exposures. Toxicol. Appl. Pharmacol. 170, 79-87.
Dorman, D. C., Struve, M. F., James, R. A., McManus, B. E., Marshall, M. W., and Wong, B. A. (2001). Influence of dietary manganese on the pharmacokinetics of inhaled manganese sulfate in male CD rats. Toxicol. Sci. 60, 242-251.
Boogaard, P. J., de Kloe, K. P., Sumner, S. C. J., van Elburg, P. and Wong, B. A. (2000). Disposition of [ring-U-14C]styrene in rats and mice exposed by recirculating nose-only inhalation. Toxicol. Sci. 58, 161-172.
Constan, A. A., Sprankle, C. S., Peters, J. M., Kedderis, G. L., Everitt, J. I., Wong, B. A., Gonzalez, F. L., and Butterworth, B. E. (1999). Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice. Toxicol. Appl. Pharmacol. 160, 120-126.
Gelzleichter, T. R., Bermudez, E., Mangum, J. B., Wong, B. A., Janszen, D. B., Moss, O. R., and Everitt, J. I. (1999). Comparison of pulmonary and pleural responses of rats and hamsters to inhaled refractory ceramic fibers. Toxicol. Sci. 49, 93-101.
Medinsky, M. A., Wolf, D. C., Cattley, R. C., Wong, B., Janszen, D. B., Farris, G. M., Wright, G. A., and Bond, J. A. (1999). Effects of a thirteen-week inhalation exposure to ethyl tertiary butyl ether on Fisher-344 rats and CD-1 mice. Toxicol. Sci. 51, 108-118.
Wong, B. A. (1999). Inhalation exposure systems design, methods, and operation. In Toxicology of the Lung, 3rd edition, (Gardner, D. E., Crapo, J. D., and McClellan, R. O., editors), pp. 1-53. Taylor & Francis, Philadelphia, PA.
Vitarella, D., James, R. A., Miller, K. L., Struve, M. F., Wong, B. A., and Dorman, D. C. (1998). Development of an inhalation system for the simultaneous exposure of rat dams and pups during developmental neurotoxicity studies. Inhal. Toxicol. 10, 1095-1117.