Scientists
Harvey J. Clewell, III, Ph.D., DABT
 |
Education
B.A., chemistry, Bradley University, Peoria, Illinois, 1969.
M.A., physical chemistry, Washington University, St. Louis, Missouri, 1971.
Ph.D., toxicology, University of Utrecht, Utrecht, The Netherlands, 2007.
Diplomate, American Board of Toxicology.
Research
My research interests are in the areas of pharmacokinetic modeling, toxicology, and chemical risk assessment. The focus of my work is on the use of tissue dosimetry and mode-of-action information in chemical safety and risk assessment and the application of physiologically based pharmacokinetic modeling to risk assessment and the interpretation of human biomonitoring data.
Selected Publications
Gentry, P.R., McDonald, T.B., Sullivan, d.e., Shipp, A.M., Yager, J.W., and Clewell, H.J., III. (2008). Analysis of genomic dose-response information on arsenic to inform key events in a mode of action for carcinogenicity. Environmental and Molecular Mutagenesis, in press.
Kenyon, E.M., Hughes, M.F., Adair, B.M., Highfill1, J.H., Crecelius, E.A., Clewell, H.J., andYager, J.W. (2008). Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water. Toxicol. Appl. Pharmacol., in press.
Nong, A., Tan, Y.-M., Krolski, M., Wang, J., Lunchick, C., Conolly, R.B., and Clewell, H.J. (2008). Bayesian calibration of a physiologically based pharmacokinetic/ pharmacodynamic model of carbaryl cholinesterase inhibition. J. Toxicol. Environ. Health, in press.
Clewell, H.J., Andersen, H.J., and Blaauboer, B.J. (2008). On the incorporation of chemical-specific information in risk assessment. Toxicology Letters, [Epub ahead of print].
Andersen, M.E., Clewell, H.J.. 3rd, Bermudez, E., Willson, G.A., and Thomas, R.S. (2008). Genomic Signatures and Dose Dependent Transitions in Nasal Epithelial Responses to Inhaled Formaldehyde in the Rat. Toxicol Sci., [Epub ahead of print].
Clewell, H. J., Tan, Y. M., Campbell, J.L., and Andersen, M.E. (2008). Quantitative interpretation of human biomonitoring data. Tox. Appl. Pharmacol., [Epub ahead of print].
Bogen, K.T., Benson, J.M., Yost, G.S., Morris, J.B., Dahl, A.R., Clewell, H.J. 3rd, Krishnan, K., and Omiecinski, C.J. (2008). Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action. Reg Tox Pharm. 51(2), Suppl 1:27-36.
Zhang Q., Pi J., Woods C.G., Jarabek A.M., Clewell H.J. III, and Andersen M.E. ((2008)). Hormesis and Adaptive Cellular Control Systems. Dose-Response. 6(2):196-208.
Loizou G, Spendiff M, Barton HA, Bessems J, Bois FY, d'Yvoire MB, Buist H, Clewell HJ 3rd, Meek B, Gundert-Remy U, Goerlitz G, Schmitt W. (2008). Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps. Regul Toxicol Pharmacol. 50:400-411.
Nong, A., Teeguarden, J.G., Clewell, H.J., 3rd, Dorman, D.C., and Andersen, M.E. (2008). Pharmacokinetic modeling of manganese in the rat IV: Assessing factors that contribute to brain accumulation during inhalation exposure. J Toxicol Environ Health A. 71(7):413-426.
Dorman DC, Struve MF, Wong BA, Gross EA, Parkinson C, and Willson GA, Tan YM, Campbell JL, Teeguarden JG, Clewell HJ III, and Andersen ME. (2008). Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation. Inhal. Toxicol. 20(3):245-256.
Schroeter JD, Kimbell JS, Gross EA, Willson GA, Dorman DC, Tan YM, and Clewell HJ III. (2008). Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein. Inhal. Toxicol. 20(3):227-244.
Tan, Y.M, Clewell, H.J., and Andersen, M.E. (2008). Time dependencies in perfluorooctylacids disposition in rat and monkeys: A kinetic analysis. Toxicology Letters 177(1):38-47.
Clewell, R.A. and Clewell, H.J. (2008). Development and Specification of Physiologically Based Pharmacokinetic Models for Use in Risk Assessment. Reg. Tox. Pharm., 50:129-143.
Teeguarden, J., Gearhart, J.M., Clewell, H.J., III, Covington, T.R. and Andersen, M.E. (2008). Pharmacokinetic modeling of manganese. I. Dose-dependencies of uptake and elimination. J. Toxicol. Environ. Health, 70(18):1493-1504.
Teeguarden, J.G., Dorman, D.C., Nong, A., Covington, T.R., Clewell, H.J., III, and Andersen, M.E. (2008). Pharmacokinetic modeling of manganese. II. Hepatic processing after ingestion and inhalation. J. Toxicol. Environ. Health, 70(18):1505-1514.
Teeguarden, J.G., Dorman, D.C., Covington, T.R., Clewell, H.J., III, Nong, A., and Andersen, M.E. (2007). Pharmacokinetic modeling of manganese. III. Physiological approaches accounting for background and tracer kinetics. J. Toxicol. Environ. Health, 70(18):1515-1526.
Liao, K.H., Tan, Y.-M., Conolly, R.B., and Clewell, H.J. (2007). Bayesian estimation of pharmacokinetic and pharmacodynamic parameters in a mode-of-action based cancer risk assessment for chloroform. Risk Anal., 27(6):1535-1551.
Liao, K.H., Tan, Y.-M., and Clewell, H.J. (2007). Development of a screening approach to interpret human biomonitoring data on volatile organic compounds (VOCs). Risk Anal., 27(5):1223-1236.
Allen, B.A., Hack, C.E., and Clewell, H.J. (2007). Use of Markov chain Monte Carlo analysis with a physiologically based pharmacokinetic model of methylmercury to estimate exposures in U.S. women of childbearing age. Risk Anal. 27(4):947-959.
Tan, Y.-M., Liao, K.H., and Clewell, H.J. (2007). Reverse dosimetry: Interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling. J. of Exposure Science and Environmental Epidemiology, 17:591-603.
Clewell, H.J., Thomas, R.S., Gentry, P.R., Crump, K.S., Kenyon, E.M., El-Masri, H.A., Yager, J.W. (2007). Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: A progress report. Toxicol. Appl. Pharmacol. 222:388-398.
Bahadori, T., Phillips, R.D., Money, C.D., Quackenboss, J.J., Clewell, H.J., Bus, J.S., Robison, S.H., Humphris, C.J., Parekh, A.A., Osborn, K., Kauffman, R.M. (2007). Making sense of human biomonitoring data: Findings and recommendations of a workshop. J Expo Sci Environ Epidemiol. (4):308-313.
Thomas, R.S., Allen, B.C., Nong, A., Yang, L., Bermudez, E., Clewell, H.J. 3rd, and Andersen, M.E. (2007). A Method to Integrate Benchmark Dose Estimates with Genomic Data to Assess the Functional Effects of Chemical Exposure. Toxicol Sci. 98(1):240-248
Clewell, R. A., Merrill, E. A., Gearhart, J. M., Robinson, P. J., Sterner, T. R., Mattie, D. R., and Clewell, H. J. III. (2007). Perchlorate and radioiodide kinetics across life-stages in the human: Using PBPK models to predict dosimetry and thyroid inhibition and sensitive subpopulations based on developmental stage. J. Toxicol. Environ. Health, Part A 70(5), 408-428.
Covington, T. R., Gentry, P. R., VanLandingham, C. B., Andersen, M. E., Kester, J. E., and Clewell, H. J. (2007). The use of Markov chain Monte Carlo uncertainty analysis to support a public health goal for perchloroethylene. Regul. Toxicol. Pharmacol. 47(1), 1-18.
Hack, C. E., Covington, T. R., Lawrence, G., Shipp, A. M., Gentry, P. R., Yager, J. A., and Clewell, H. J. III. (2007). A pharmacokinetic model of the intracellular dosimetry of inhaled nickel. J. Toxicol. Environ. Health, Part A 70, 445-464.
Thomas, R. S., Allen, B. C., Nong, A., Yang, L., Bermudez, E., Clewell, H. J. 3rd, and Andersen, M. E. (2007). A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure. Toxicol. Sci. 98(1), 240-248.
Andersen, M. E., Clewell, H. J., Tan, Y.-M., Butenhoff, J. L., and Olsen, G. W. (2006). Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys - Probing the determinants of long plasma half-lives. Toxicology 227(1-2), 156-164.
Clewell, H. J. and Andersen, M. E. (2006). Response to comments by Caldwell et al. on article "Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: An example with trichloroethylene. Crit. Rev. Toxicol. 36, 295-298.
Covington, T. R., Clewell, H. J., and Fisher, J. W. (2006). Development of a physiologically-based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment. AFRL-HE-WP-TR-2006-0049, U.S. Air Force Research Laboratory, Wright-Patterson AFB, OH.
David, R. M., Clewell, H. J., Gentry, P. R., Covington, T. R., Morgott, D. A., and Marino, D. J. (2006). Revised assessment of cancer risk to dichloromethane II: Application of probabilistic methods to cancer risk determination. Regul. Toxicol. Pharmacol. 45, 55-65.
Dorman, D. C., Struve. M. F., Clewell, H. J. 3rd, and Andersen, M. E. (2006). Application of pharmacokinetic data to the risk assessment of inhaled manganese. Neurotoxicology 27, 752-764.
Hack, C. E., Chiu, W. A., Zhao, Q. J., and Clewell, H. J. (2006). Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites. Regul. Toxicol. Pharmacol. 46(1), 63-83.
Marino, D. J., Clewell, H. J., Gentry, P. R., Covington, T. R., Hack, C. E., David, R. M., and Morgott, D. A. (2006). Revised assessment of cancer risk to dichloromethane I: Bayesian PBPK and dose-response modeling in mice. Regul. Toxicol. Pharmacol. 45, 44-54.
Shipp, A., Lawrence, G., Gentry, R., McDonald, T., Bartow, H., Bounds, J., Macdonald, N., Clewell, H., Allen, B., Van Landingham, C. (2006). Acrylamide: review of toxicity data and dose-response analyses for cancer and noncancer effects. Crit. Rev. Toxicol. 36(6-7):481-608.
Tan, Y.-M., Liao, Kai H., Conolly, R. B., Blount, B. C., Mason, A. M., and Clewell, H. J. (2006). Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform. J. Toxicol. Environ. Health Part A 69, 1727-1756.
Clewell, H. J., Gentry, P. R., Kester, J. E., and Andersen, M. E. (2005). Evaluation of physiologically based pharmacokinetic models in risk assessment: An example with perchloroethylene. Crit. Rev.Toxicol. 35, 413-433.