Scientists
Miyoung Yoon, Ph.D.
Education
Ph.D., Pharmacy, Seoul National University, Seoul, Korea (1999)
M.S., Pharmacy, Seoul National University, Seoul, Korea (1995)
B.S., Pharmacy, Seoul National University, Seoul, Korea (1993)
Research
My research at The Hamner Institutes for Health Sciences focuses on developing a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for N-methyl carbamate exposures and its application to risk assessments and interpretation of human biomonitoring data. My research emphasis will be on developing a means to integrate in vitro data, pharmacokinetic data, and statistical tools to efficiently develop a human PBPK/PD model for carbaryl exposure, which can contribute to reduce the need for the use of in vivo human data.
Selected Publications
M. Yoon and H.A. Barton: Predicting maternal rat and pup exposures: How different are they? (accepted for publication, Toxicological Sciences 2007; doi: 10.1093/toxsci/kfm286)
M. Yoon, M.C. Madden, and H.A. Barton: Extrahepatic metabolism by CYP2E1 in PBPK modeling of lipophilic volatile organic chemicals: Impacts on metabolic parameter estimation and prediction of dose metrics, Journal of Toxicology and Environmental Health, Part A, 70: 1527–1541 (2007)
S.J. Lim, Y.S. Jung, M.Y. Yoon and Y.C. Kim: Comparative effects of dimethylsulfoxide on metabolism and toxicity of carbon tetrachloride and dichloromethane, Journal of Applied Toxicology 27(1): 25-31 (2007)
M. Yoon, M.C. Madden, and H.A. Barton: Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development, Toxicological Sciences 89(2):386-398 (2006)
M.Y. Yoon, S.J. Lee, B.H. Lee, J.H. Chung and Y.C. Kim: Effects of dimethylsulfoxide on metabolism and toxicity of acetaminophen in mice, Biological and Pharmaceutical Bulletin 29(8): 1618-1624 (2006)