Scientists
Courtney Woods, Ph.D.
Education
Ph.D., Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, 2007
M.S., Chemical Engineering, Georgia Institute of Technology, 2003
B.S., Chemical Engineering, University of Tennessee- Knoxville, 2001
Research
My research involves using genomics techniques to characterize transcriptional regulatory networks. I am currently investigating the role of kinase signaling in Nrf2-mediated regulation of antioxidant response. I am also conducting a study to identify downstream transcriptional targets of PPARα in human and mouse hepatocytes. Experimental findings from both studies will be used to generate pathway circuitry maps for computational models that describe dose and time-dependent changes in key transcription factors. Collectively, this research will be useful in understanding molecular mechanisms involved in these two important toxicity pathways and the models can be used as prototypes for probing other toxicity pathways.
Selected Publications
Zhang Q., Pi J., Woods C.G., Andersen M.E. A systems biology perspective on Nrf2-mediated antioxidant response. In press at Toxicol Appl Pharmacol.
Pi., J., Zhang, Q., Fu, J., Woods, C.G., Andersen, M.E., Collins, S.ROS signaling , oxidative stress and Nrf2 in pancreatic beta-cell function. In Press at Toxicol Appl Pharm
Woods, C.G., Fu, J., Xue, P., Hou, Y., Pluta, L.J., Yang, L., Zhang, Q. Thomas, R.S., Andersen, M.E., Pi, J. Zhang, Qiang., Thomas, R.S., Wang, J., Wolf, C.R., Andersen, M.E., Pi, J (2009). Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages. Toxicol Appl Pharmacol, 238(1):27-36.
Zhang, Q., Pi, J., Woods, C.G., Andersen, M.E. Phase I and II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses (2009). Toxicol Appl Pharm 237 (3):345–356.
Ross, P.K., Woods, C.G., Bradford, B.U., Koysk, O., Gatti, D.M., Cunningham, M.L., Rusyn, I. Time
course comparison of xenobiotic activators of CAR and PPARα in mouse liver (2009).Toxicol ApplPharm .235(2):199-207.
Zhang, Q., Pi, J., Woods, C.G., Jarabek, A.M., Clewell, H.J., Andersen, M.E. Hormesis and adaptive
cellular control systems (2008). Dose Response. 6(2) 196-208.
Pi, J., Zhang, Q., Woods, C.G., Wong, V., Collins, S., Andersen, M.E. Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid (2008). Toxicol Appl Pharm.226(3):236-43.
Woods, C.G., Kosyk, O., Bradford, B.U., Ross, P.K., Quo, P., Ibrahim, JG., Cunningham, M.L., Rusyn., I. Time-course investigation of PPARα- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression (2007). Toxicol Appl Pharm .225(3):267-77.
Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler, TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, Kayton RJ, Kerr KF, Kosyk O, Lobenhofer EK, Sieber SO, Vliet PA, Weis BK, Wolfinger R, Woods CG, Freedman JH, Linney E, Kaufmann WK, Kavanagh TJ, Paules RS, Rusyn I, Samson LD, Spencer PS, Suk W, Tennant RJ, Zarbl H; Members of the Toxicogenomics Research Consortium Multi-Center Study of Acetaminophen Hepatotoxicity Reveals the Importance of Biological Endpoints in Genomic Analyses (2007). Toxicol Sci. 99(1):326-37.
Porgribny, I.P., Tryndyak, V.P., Woods, C.G., Wiit, S.E., Rusyn, I. Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon Peroxisome Proliferator Activated Receptor alpha (2007). Mutat. Res. 625(1-2):62-71
Woods, C.G., Burns, A.M., Bradford, B.U., Ross, P.K., Kosyk, O., Swenberg, J.A., Cunningham, M.L., Holland, S.M., Rusyn, I. WY-14,643-induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase (2007). Toxicol. Sci. 98(2):366-74.
Woods, C.G., Vanden Heuval, J.P., Rusyn, I. Genomic Profiling in Nuclear Receptor- Mediated Toxicity. (2007). Toxicol Pathol. 35(4):474-94.
Woods, C.G., Burns, A.M., Maki, A., Bradford, B.U., Cunningham, M.L., Connor, M.D., Kadiiska, M.B.,
Mason, R.P., Peters, J.P., Rusyn, I. Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator activated receptor-alpha, but not NADPH oxidase (2007). Free Radic Biol Med. 42(3):335-42.
Kono, H., Woods, C.G., Maki, A., Connor, H., Mason, R., Rusyn, I., Fujii, H. Electron spin resonance and
spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage (2006). Free Radic Res. 40(6):579-88.