Scientists & Research

Recent Research Publications

Liu, H.Y., Wen, G.B., Han, J.M., Hong, T., Zhuo, D., Liu, Z., and W. Cao. Inhibition of gluconeogenesis in primary hepatocytes by stromal-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway. J. Biol. Chem., 2008, 283: 30642-9.

Liu, H.Y., Schnaidman, E.Y., Hong, T., Han, J., Zhuo, D., Liu, Z., W. Cao. Prolonged exposure to insulin suppresses mitochondrial production in primary hepatocytes. J. Biol. Chem., 2009, 284: 14087-95.

Li G, Barrett EJ, Ko SH, Cao W, Liu Z. Insulin and IGF-I Receptors Differentially Mediate Insulin-Stimulated Adhesion Molecule Production by Endothelial Cells. Endocrinology, accepted on May 7, 2009

Liu, H.Y., Hong, T., Han, J., Zhuo, D., Liu, Z., W. Cao. Increased Basal Level of Akt-Dependent Insulin Signaling Is Associated with Decreased Mitochondrial Production and Increased Ectopic Fat Accumulation and Oxidative Stress in the Presence of Insulin Resistance. AJP: Endocrinology and Metabolism, Accepted on June 14, 2009 (available online)

Liu, H.Y., Hong, T., Han, J., Zhuo, D., Liu, Z., W. Cao. Insulin Is a Stronger Inducer of Insulin Resistance than Hyperglycemia in Mice with Type 1 Diabetes Mellitus (T1DM). J. Biol. Chem., accepted in July 2009 (available online)

Liu, H.Y., Han, J.M., Hong, T., Zhuo, D.G., Shi, J.B., Liu, Z., W. Cao. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J. Biol. Chem., Accepted on September 16, 2009 (available online).

Kumar N, Wang H, Liu D, Collins S Liver X receptor is a regulator of orphan nuclear receptor NOR-1 gene transcription in adipocytes. 2009 International Journal of Obesity (in press).

Kumar N, Liu D, Wang H, Robidoux J, Collins S. Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription. Mol Endocrinol. (2008) May;22(5):1057-64. Epub 2008 Jan 31.

Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Czech MP, Mangelsdorf DJ, Collins S. Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol. (2008) Apr; 28(7):2187-200.

Moukdar F, Robidoux J, Lyght O, Pi J, Daniel KW, Collins S (2008) Reduced antioxidant capacity and diet-induced athersclerosis in Ucp2-deficient mice. J. Lipid Res. 50:59-70.

Ménache, M.G., Hofmann, W., Asgharian, B., and Miller, F.J. (2008). Airway Geometry Models of Children’s Lungs for use in Dosimetry Modeling Inhalation Toxicology 20:101-126.

Nazridoust, K. and Asgharian, B. (2008). Prediction of Airflow and Particle Deposition in the Human Lung Inhalation Toxicology 20:595-610.

Ginsburg, G., Asgharian, B., Kimbell, J., Ultman, J., and Jarabek, A.M. (2008). Modeling approaches for estimating the dosimetry of toxicant in children Journal of Toxicology and Environmental Health 71:161-195.

Gentry, P.R., McDonald, T.B., Sullivan, d.e., Shipp, A.M., Yager, J.W., and Clewell, H.J., III. (2008). Analysis of genomic dose-response information on arsenic to inform key events in a mode of action for carcinogenicity. Environmental and Molecular Mutagenesis, in press.

Kenyon, E.M., Hughes, M.F., Adair, B.M., Highfill1, J.H., Crecelius, E.A., Clewell, H.J., and Yager, J.W. (2008). Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water. Toxicol. Appl. Pharmacol., in press.

Nong, A., Tan, Y.-M., Krolski, M., Wang, J., Lunchick, C., Conolly, R.B., and Clewell, H.J. (2008). Bayesian calibration of a physiologically based pharmacokinetic/ pharmacodynamic model of carbaryl cholinesterase inhibition. J. Toxicol. Environ. Health, in press.

Clewell, H.J., Andersen, H.J., and Blaauboer, B.J. (2008). On the incorporation of chemical-specific information in risk assessment. Toxicology Letters, [Epub ahead of print].

Andersen, M.E., Clewell, H.J.. 3rd, Bermudez, E., Willson, G.A., and Thomas, R.S. (2008). Genomic Signatures and Dose Dependent Transitions in Nasal Epithelial Responses to Inhaled Formaldehyde in the Rat. Toxicol Sci., [Epub ahead of print].

Clewell, H. J., Tan, Y. M., Campbell, J.L., and Andersen, M.E. (2008). Quantitative interpretation of human biomonitoring data. Tox. Appl. Pharmacol., [Epub ahead of print].

Bogen, K.T., Benson, J.M., Yost, G.S., Morris, J.B., Dahl, A.R., Clewell, H.J. 3rd, Krishnan, K., and Omiecinski, C.J. (2008). Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action. Reg Tox Pharm. 51(2), Suppl 1:27-36.

Zhang Q., Pi J., Woods C.G., Jarabek A.M., Clewell H.J. III, and Andersen M.E. (2008). Hormesis and Adaptive Cellular Control Systems. Dose-Response. 6(2):196-208.

Loizou G, Spendiff M, Barton HA, Bessems J, Bois FY, d'Yvoire MB, Buist H, Clewell HJ 3rd, Meek B, Gundert-Remy U, Goerlitz G, Schmitt W. (2008). Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps. Regul Toxicol Pharmacol. 50:400-411.

Nong, A., Teeguarden, J.G., Clewell, H.J., 3rd, Dorman, D.C., and Andersen, M.E. (2008). Pharmacokinetic modeling of manganese in the rat IV: Assessing factors that contribute to brain accumulation during inhalation exposure. J Toxicol Environ Health A. 71(7):413-426.

Dorman DC, Struve MF, Wong BA, Gross EA, Parkinson C, and Willson GA, Tan YM, Campbell JL, Teeguarden JG, Clewell HJ III, and Andersen ME. (2008). Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation. Inhal. Toxicol. 20(3):245-256.

Schroeter JD, Kimbell JS, Gross EA, Willson GA, Dorman DC, Tan YM, and Clewell HJ III. (2008). Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein. Inhal. Toxicol. 20(3):227-244.

Tan, Y.M, Clewell, H.J., and Andersen, M.E. (2008). Time dependencies in perfluorooctylacids disposition in rat and monkeys: A kinetic analysis. Toxicology Letters 177(1):38-47.

Clewell, R.A. and Clewell, H.J. (2008). Development and Specification of Physiologically Based Pharmacokinetic Models for Use in Risk Assessment. Reg. Tox. Pharm., 50:129-143.

Teeguarden, J., Gearhart, J.M., Clewell, H.J., III, Covington, T.R. and Andersen, M.E. (2008). Pharmacokinetic modeling of manganese. I. Dose-dependencies of uptake and elimination. J. Toxicol. Environ. Health, 70(18):1493-1504.

Teeguarden, J.G., Dorman, D.C., Nong, A., Covington, T.R., Clewell, H.J., III, and Andersen, M.E. (2008). Pharmacokinetic modeling of manganese. II. Hepatic processing after ingestion and inhalation. J. Toxicol. Environ. Health, 70(18):1505-1514.

Liu J, Wu Q, Lu Y, Pi J. New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction. Biochemical Pharmacol. (2008); (in press)

Pi J, Diwan BA, Qu W, Liu J, Sun Y, Miroslav Styblo, Waalkes MP. Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med. (2008); 45:651-658.

Li X, Pi J, Li B, Xu Y, Jin Y, Sun G. Urinary arsenic speciation and its correlation with 8-OHdG level in patients exposed to arsenic through coal burning. Bull Environ. Contam. Toxicol. (2008); (in press).

Pi J, Zhang Q, Wong V, Woods C, Collins S, Andersen ME. Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid. Toxicol Appl Pharmacol. (2008); 226:236-43.

Zhu L, Pi J, Wachi S, Andersen ME, Wu R, Chen Y. Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid (HOCl) challenge by transcription profiling. Am J Respir Cell Mol Biol. (2008); 294:L469-77.

Andersen, M.E., Krewski, D., Mantus, E., and Zeise, L. (2008). Toxicity Testing in the 21st Century.

Clewell, H.J., III, Tan, Y.M., Campbell, J.L., and Andersen, M.E. (2008). Quantitative Interpretation of Human Biomonitoring Data. Toxicol. Appl. Pharrmacol., 2008 May 4 epub PMID: 18589468.

Reddy, M.B., Domoradzki, J., Dobrev, I.D., Jovanic, M.L., Crofoot, S., McNett, D.A., Tobin, J.M., Utell, M.J., Morrow, P.E., Plotzke, K.P., and Andersen, M.E. (2008). Physiological modeling of the inhalation kinetics of decamethylcyclopentasiloxane (D5) in rats and humans. Toxicol. Sci., 2008 Jun 26. PMID: 18583370

McLanahan, E.D., Andersen, M.E. and Fisher, J.W. (2008). Biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat: evaluation of iodide deficiency. Tox. Sci., 102, 241-253.

Andersen, M.E., Reddy, M.B., and Plotzke, K.P. (2008). Are Highly Lipophilic Volatile Organic Compounds Expected to Bioaccumulate on Repeated Exposures? Toxicol. Ltrs., 179, 85-92.

Andersen, M.E., Clewell, H.J., III, Bermudez, E., Wilson, G.A., and Thomas, R.S. (2008). Genomic signatures and dose dependent transitions in nasal epithelial responses to inhaled formaldehyde in rats. Toxicol. Sci., 2008 May21 epbub.

Pi J., Zhang Q., Woods C.G., Wong V., Collins S., and Andersen M.E. (2008). Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid. Toxicology and Applied Pharmacology. 226(3): 236-243.

Zhang Q., Pi J., Woods C.G., Jarabek A.M., Clewell H.J. III, and Andersen M.E. (2008). Hormesis and Adaptive Cellular Control Systems. Dose-Response. 6(2):196-208.

Liu, H.Y., Zhuo D., Collins, Q.F., Xiong, Y., Lupo, E.G., and W. Cao. Suppression of hepatic gluconeogenesis by Human neutrophil peptides through a novel signaling pathway distinct from insulin. J. Biol. Chem., (2008), 283: 12056-63.